Supply high quality 99.00% Tofacitinib citrate CAS#540737-29-9 CAS NO.540737-29-9

Tofacitinib citrate CAS#540737-29-9
High and stable quality
Competitive Price

Tofacitinib citrate Basic information:
Product Name: Tofacitinib citrate
Synonyms: 1-PIPERIDINEPROPANENITRILE, 4-METHYL-3-(METHYL-7H-PYRROLO[2,3-D]PYRIMIDIN

-4-YLAMINO)-BETA-OXO-, (3R,4R)-, 2-HYDROXY-1,2,3-PROPANETRICARBOXYLATE (1:1);1-

Piperidinepropanenitrile, 4-Methyl-3-(Methyl-7H-pyrrolo[2,3-d]pyriMidin-4-ylaMino)-

β-oxo-, (3R,4R)-, 2-hydroxy-1,2,3-propanetricarboxylate (1:1);Tofacitinib citrate

(CP-690550);Tofacitinib citrate;Tasocitinib citrate;Tasocitinib citric acid

s...;Xeljanz;CP-690550 (Tofacitinib citrate)
CAS: 540737-29-9
MF: C16H20N6O.C6H8O7
MW: 504.497
Product Categories: Inhibitor

Description:
 Tofacitinib (formerly tasocitinib, CP-690550) is a drug being investigated by Pfizer for the treatment of rheumatoid arthritis (RA), psoriasis, inflammatory bowel disease, and other immunological diseases, as well as for the prevention of organ transplant rejection. It is an inhibitor of the enzyme Janus kinase 3 (JAK3), which means that it interferes with the JAK-STAT signaling pathway that transmits information outside the cell into the cell nucleus, influencing DNA transcription. Recently it has been shown in a murine model of established arthritis, tofacitinib rapidly improved disease by inhibiting the production of inflammatory mediators and suppressing STAT1-dependent genes in joint tissue. This efficacy in this disease model correlated with the inhibition of both JAK1 and 3 signaling pathways, suggesting that tofacitinib may exert therapeutic benefit via pathways that are not exclusive to inhibition of JAK3.

Packaage: 50g 500g 1kg in a Al foil bag & 25kg/barrel. 2. The packaging can be customised.

Storage: In cool, dry container, avoid heat and light.