Aprepitant CAS NO.170729-80-3

Chemical Properties Appearance: Off-White to Light Yellow Cyrstalline Solid Molecular Weight: 534.43 Density: 1.51 g/cm3 Refractive index: 1.564 Usage: A novel selective neurokinin-1 (NK-1) receptor antagonist. In vitro studies using human liver microsomes indicate that Aprepitant is metabolised primarily by CYP3A4 with minor metabolism by CYP1A2 and CYP2C19, and no metabolism by CYP2D6, CYP2C9, or CYP2

Name:

Aprepitant (Related Reference)

Molecular Formula:

C₂₃H₂₁F₇N₄O₃

CAS Registry Number:

170729-80-3

Synonyms:

3H-1,2,4-Triazol-3-one,5-[[2-[1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-1,2-dihydro-,[2R-[2a(R*),3a]]-; Emend; L 754030; MK 0869; MK 869; ONO7436;

InChI:

InChI=1/C23H21F7N4O3/c1-12(14-8-15(22(25,26)27)10-16(9-14)23(28,29)30)37-20-19(13-2-4-17(24)5-3-13)34(6-7-36-20)11-18-31-21(35)33-32-18/h2-5,8-10,12,19-20H,6-7,11H2,1H3,(H2,31,32,33,35)/t12-,19+,20-/m1/s1

Molecular Structure:

Chemical Properties

Appearance:

Off-White to Light Yellow Cyrstalline Solid

Molecular Weight:

534.43

Density:

1.51 g/cm³

Refractive index:

1.564

Usage:

A novelive neurokinin-1 (NK-1) receptantagonist. In vitro studies using human liver microsomes indicate that Aprepitant is metabolised primarily by CYP3A4 with minmetabolism by CYP1A2 CYP2C19, no metabolism by CYP2D6, CYP2C9, CYP2

Safety Data of 170729-80-3