Rutin CAS NO.153-18-4

1.rutoside trihydrate/rutin 
2.cas no.:153-18-4 
3.chinese natural herb extract 
4.purity:95% 98%. 
5.antioxidant

Specification

Structure

Description

Rutin, also called rutoside, quercetin-3-O-rutinoside, rutoside trihydrate and sophorin, is the glycoside between the flavonol quercetin and the disaccharide rutinose (α-L-rhamnopyranosyl-(1→6))-β-D-glucopyranose). In the fava d'anta tree, the synthesis is done via a rutin synthase activity.Rutin (quercetin rutinoside), like quercitrin, is a glycoside of the flavonoid quercetin. As such, the chemical structures of both are very similar, with the difference existing in the hydroxyl functional group. Both quercetin and rutin are used in many countries as medications for blood vessel protection, and are ingredients of numerous multivitamin preparations and herbal remedies.

Rutin is one of the phenolic compounds found in the invasive plant species Carpobrotus edulis and contributes to the antibacterial and antioxidant properties of the plant. Its name comes from the name of Ruta graveolens, a plant that also contains rutin.

Occurrence in food

Rutin is a citrus flavonoid glycoside found in many plants including buckwheat, the leaves and petioles of Rheumspecies, and asparagus. Tartary buckwheat seeds have been found to contain more rutin (about 0.8-1.7% dry weight) than common buckwheat seeds (0.01% dry weight). Rutin is also found in the fruit of the fava d'anta tree (from Brazil), fruits and flowers of the pagoda tree, fruits and fruit rinds (especially the citrus fruits orange, grapefruit, lemon, and lime) and apple; berries such as mulberry, ash tree fruits, aronia berries and cranberries.

Rutin is one of the primary flavonols found in 'clingstone' peaches.

Functions

It can combine with cations, supplying nutrients from the soil to the cells in plants. In humans, it attaches to the iron ion Fe²⁺, preventing it from binding to hydrogen peroxide, which would otherwise create a highly reactive free radical that may damage cells. It is also an antioxidant.

Furthermore, it has been shown to inhibit in vitro the vascular endothelial growth factorin subtoxic concentrations, so acts as an inhibitor of angiogenesis. This finding may have potential relevance for the control of some cancers.

Health effects

1.Rutin inhibits platelet aggregation, as well as decreases capillary permeability, making the blood thinner and improving circulation.

2.Rutin shows anti-inflammatory activity in some animal and in vitro models.

3.Rutin inhibits aldose reductase activity. Aldose reductase is an enzyme normally present in the eye and elsewhere in the body. It helps change glucose into the sugar alcohol sorbitol.

4.Recent studies show rutin could help prevent blood clots, so could be used to treat patients at risk of heart attacks and strokes.

5.Some evidence also shows rutin can be used to treat hemorrhoids, varicosis, and microangiopathy.

6.Rutin increases thyroid iodide uptake in rats without raising serum T3 or T4.

7.Rutin is also an antioxidant; compared to quercetin, acacetin, morin, hispidulin, hesperidin, and naringin, it was found to be the strongest. However, in other trials, the effects of rutin were lower or negligible compared to those of quercetin.

Hydroxyethylrutosides, synthetic hydroxyethyl acetylations of rutin, are used in the treatment of chronic venous insufficiency.

In veterinary medicine

Rutin may have a veterinary use in the management of chylothorax in dogs and cats.

Metabolism

The enzyme quercitrinase can be found in Aspergillus flavus. It is an enzyme in the rutin catabolic pathway.